The molecules that changed perfumery
Natali Profumeria · 1 min read · November 7, 2026
Many of the sensations we love in today's fragrances come from synthetic molecules: the velvety wood of Iso E Super, the transparent jasmine of Hedione, the saline amber of Ambroxan, the sea of Calone, the violet of ionone. They are not "fake": they are tools that allow perfumers to create scents that nature alone does not provide.
The molecules to know
- Ionone: the violet molecule, discovered at the end of the 19th century. It is one of the first synthetic molecules in modern perfumery. See the violet note.
- Hedione: a bright and transparent jasmine, which gives air and diffusion to a fragrance.
- Calone: smells of the sea and watermelon; it is the base of many marine fragrances. See marine notes.
- Iso E Super: a soft and velvety wood, which some people smell very strongly and others almost not at all.
- Ambroxan: synthetic ambergris, saline and warm. See ambroxan.
- Cashmeran: a warm, musky wood. See cashmeran.
Single-molecule fragrances
Escentric Molecules built Molecule 01 on Iso E Super alone. It is the best way to experience a "naked" molecule, and to understand why it smells different on everyone's skin. There is also Molecule 01 + Ginger, with ginger. All molecular fragrances are in the molecular collection.
Natural versus synthetic?
It is not a competition: great fragrances use both. We talk about it in natural or synthetic.
Frequently asked questions
Why can't some people smell Iso E Super?
Because some people are less sensitive to certain molecules: it is a difference in the nose, not the fragrance.
Is a fragrance with synthetic molecules of lower quality?
No. Synthetic molecules are used in almost all fragrances, even the most prestigious ones. Quality depends on how they are used.
Products in this article
Molecule 01
from€150,00
Molecule 01 + Ginger
from€165,00Read also
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